Does Schwann cell dedifferentiation originate dermal neurofibromas?
نویسندگان
چکیده
منابع مشابه
Does Schwann cell dedifferentiation originate dermal neurofibromas?
Dermal neurofibromas are characteristic of neurofibromatosis type one (NF1), and their developmental origin still unsolved. Although NF1 loss is required for neurofibroma initiation, some features of these benign tumors resemble a skin injury state and cutaneous trauma or other insults might support tumor development. Since adult terminal Schwann cells ensheathing nerve endings are able to dedi...
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The peripheral nerves consist of sensory nerves that transmit somatic and visceral afferent information to the brain via the spinal cord and motor nerves that convey efferent outputs of the brain to effector organs such as skeletal muscles and glands. The nerve conduction velocities (NCV) of mammalian peripheral nerves range from 10 m/s to 150 m/s, depending on the type of information being tra...
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Background: Peripheral nerve injury (PNI) is a common condition that compromises motor and sensory functions. Peripheral nerves are known to have regenerative capability and the pineal hormone, melatonin, is known to aid nerve regeneration. However, the role of Schwann cells and the pathways involved remain unclear. Thus, the aim of this study is to identify the effects of melatonin on Schwann ...
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Schwann cells are a regenerative cell type. Following nerve injury, a differentiated myelinating Schwann cell can dedifferentiate and regain the potential to proliferate. These cells then redifferentiate during the repair process. This behaviour is important for successful axonal repair, but the signalling pathways mediating the switch between the two differentiation states remain unclear. Sust...
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ژورنال
عنوان ژورنال: Experimental Dermatology
سال: 2016
ISSN: 0906-6705
DOI: 10.1111/exd.13110